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Article

In vitro and in vivo study on the secretion of the Gly367Arg mutant myocilin protein.

Molecular vision - 13 Jul 2007

Kanagavalli Janakaraj, Pandaranayaka P J Eswari, Krishnadas Subbaiah Ramasamy, Krishnaswamy Sankaran, Sundaresan Periasamy

Abstract excerpt

PURPOSE: Mutations in the myocilin gene (MYOC) leading to a perturbed outflow of aqueous in the trabecular meshwork (TM) has been associated with the pathophysiology of glaucoma. This study examines the expression of normal and mutant myocilin (Gly367Arg) in cultured TM cells. METHODS: Normal and...

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Source

Identifiers

PMID: 17679945

Genes

MYOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17679945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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In vitro and in vivo study on the secretion of the Gly367Arg mutant myocilin protein.PMID 17679945Read ↗

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Glaucoma-associated myocilin: a better understanding but much more to learn.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells.Semantic proximity Read ↗

Structural basis for anomalous cellular trafficking behavior of glaucoma-associated A427T mutant myocilinSemantic proximity Read ↗

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.Semantic proximity Read ↗

Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.Semantic proximity Read ↗

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