Article
In vitro and in vivo study on the secretion of the Gly367Arg mutant myocilin protein.
Molecular vision - 13 Jul 2007
Kanagavalli Janakaraj, Pandaranayaka P J Eswari, Krishnadas Subbaiah Ramasamy, Krishnaswamy Sankaran, Sundaresan Periasamy
Abstract excerpt
PURPOSE: Mutations in the myocilin gene (MYOC) leading to a perturbed outflow of aqueous in the trabecular meshwork (TM) has been associated with the pathophysiology of glaucoma. This study examines the expression of normal and mutant myocilin (Gly367Arg) in cultured TM cells. METHODS: Normal and mutant MYOC cDNA constructs were used to transfect the TM cells. In order to confirm the method of transfection,...
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