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Potent Bile Acid Microbial Metabolites Modulate Clostridium perfringens Virulence

28 Sept 2023

Abstract excerpt

Clostridium perfringens is a versatile pathogen, inducing diseases in the skin, intestine (such as chicken necrotic enteritis (NE)), and other organs. The classical sign of NE is the foul smell gas in the ballooned small intestine. We hypothesized that deoxycholic acid (DCA) reduced NE by inhibiting C. perfringens virulence signaling pathways. To evaluate the hypothesis, C. perfringens strains CP1 and wild-type...

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PMID: 37887718
DOI: 10.3390/pathogens12101202

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