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Article

Confidence-based somatic mutation evaluation and prioritization.

PLoS computational biology - 1 Jan 2012

Löwer Martin, Renard Bernhard Y, de Graaf Jos, Wagner Meike, Paret Claudia, Kneip Christoph, Türeci Ozlem, Diken Mustafa, Britten Cedrik, Kreiter Sebastian, Koslowski Michael, Castle John C, Sahin Ugur

Abstract excerpt

Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation detection is prone to erroneous calls, with reported validation rates near 54% and congruence between algorithms less than 50%. Here, we developed an algorithm to assign a single statistic, a...

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PMID: 23028300
DOI: 10.1371/journal.pcbi.1002714
PMCID: PMC3459886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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