Article

Evaluating discordant somatic calls across mutation discovery approaches to minimize false negative drug-resistant findings

2023-10-30

Abstract excerpt

Evaluating robustness of somatic mutation detections is essential when utilizing whole exome sequencing (WES) for treatment decision-making. A comprehensive evaluation was conducted using tumor WES from the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, in which multiple library kits sequenced identical DNA materials across three labs to benchmark analytical validity. These workflows included various...

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Literature Corpus work: 8048bd15-d6ff-5a42-b01c-3388b74dbdca
DOI: 10.1101/2023.10.26.562640

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