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Article

Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Oct 2010

Jamil Sarwat, Wang Shih Wei, Bondy Lise, Mojtabavi Shadi, Duronio Vincent

Abstract excerpt

Growth factor withdrawal from hemopoietic cells results in activation of the mitochondrial pathway of apoptosis. Members of the Bcl-2 family regulate this pathway, with anti-apoptotic members counteracting the effects of pro-apoptotic members. We investigated the effect on Mcl-1 function of mutation at a conserved threonine 163 residue (T163) in its proline, glutamate, serine, and threonine rich (PEST) region....

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Identifiers

PMID: 20921992
DOI: 10.1139/o10-004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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