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Article

ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy.

Journal of cellular and molecular medicine - 1 Mar 2015

Shi Ying, Han Yue, Xie Fang, Wang Anna, Feng Xiaokun, Li Ning, Guo Hongliang, Chen Dexi

Abstract excerpt

Inactivation of p53-mediated cell death pathways is a central component of cancer progression. ASPP2 (apoptosis stimulated protein of p53-2) is a p53 binding protein that specially stimulates pro-apoptosis function of p53. Down-regulation of ASPP2 is observed in many human cancers and is associated with poor prognosis and metastasis. In this study, ASPP2 was found to enhance L-OHP-induced apoptosis in HCT116...

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Identifiers

PMID: 25534115
DOI: 10.1111/jcmm.12435
PMCID: PMC4369811

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