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Article

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

2 Jul 2012

Abstract excerpt

Recently we have shown that the mitogen-activated protein kinase (MAPK) MAPK14/p38α is involved in resistance of colon cancer cells to camptothecin-related drugs. Here we further investigated the cellular mechanisms involved in such drug resistance and showed that, in HCT116 human colorectal adenocarcinoma cells in which TP53 was genetically ablated (HCT116-TP53KO), overexpression of constitutively active...

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PMID: 22647487
DOI: 10.4161/auto.20268

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