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Article

miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression.

Cancer letters - 1 May 2011

Li Jian, Chen Yuxiang, Zhao Jingfeng, Kong Fangren, Zhang Yangde

Abstract excerpt

In this study, we explored miR-203's role in the chemoresistance of colon cancer. We found that overexpression of miR-203 significantly decreased cell proliferation and survival, and induced cell apoptosis in the p53-mutated colon cancer cells. Importantly, miR-203 overexpression increased the cytotoxic role of paclitaxel in the p53-mutated colon cancer cells, but not in the p53 wild-type cells. We further...

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PMID: 21354697
DOI: 10.1016/j.canlet.2011.02.003

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MTDH

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