Article
The functional role of UBA1 cysteine-278 in ubiquitination.
Biochemical and biophysical research communications - 26 Oct 2012
Yang Ung, Yang Hee-Young, Kim Jeong-Sun, Lee Tae-Hoon
Abstract excerpt
Although total UBA1 levels were unchanged, after oxidation for 60 min, we observed dramatic changes in the levels of BIAM-labeled UBA1 in both the membrane and cytosol fractions that suggested oxidative stress induces translocation of UBA1 from the cytosol to the membrane. Notably, in PrdxII(-/-) oxRBCs, ubiquitination levels were reduced about 75% in the membrane fraction after 90 min, even though UBA1 levels...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.