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Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids.

Journal of virology - 15 Aug 2016

Aydemir Fikret, Salganik Maxim, Resztak Justyna, Singh Jasbir, Bennett Antonette, Agbandje-McKenna Mavis, Muzyczka Nicholas

Abstract excerpt

UNLABELLED: We previously reported that an amino acid substitution, Y704A, near the 2-fold interface of adeno-associated virus (AAV) was defective for transcription of the packaged genome (M. Salganik, F. Aydemir, H. J. Nam, R. McKenna, M. Agbandje-McKenna, and N. Muzyczka, J Virol 88:1071-1079, 2013, doi: http://dx.doi.org/10.1128/JVI.02093-13). In this report, we have characterized the defect in 6 additional...

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Identifiers

PMID: 27252527
DOI: 10.1128/JVI.00493-16
PMCID: PMC4984656

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Source receipt: pubmed, retrieved 7 Sept 2026.

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