Article

Assembly-Activating Protein Phase Separation Properties Are Required for Adeno-Associated Virus Type 2 Assembly

2025-03-11

Abstract excerpt

Adeno-associated virus serotype 2 (AAV2), a non-pathogenic parvovirus reliant on helper viruses, is studied extensively as a potential gene delivery vector. A +1 open reading frame within the cap gene encodes a nonstructural protein of 204-amino-acids termed assembly-activating protein (AAP), which has been attributed a critical role in transporting the viral capsid protein VP3 into the nucleolus for assembly. How...

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Literature Corpus work: d6915740-a0fa-5430-ad52-11ea7e3f7f66
DOI: 10.1101/2025.03.10.642135

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