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Article

Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome.

Pediatric blood & cancer - 1 Apr 2013

Chang Vivian Y, Federman Noah, Martinez-Agosto Julian, Tatishchev Sergei F, Nelson Stanley F

Abstract excerpt

BACKGROUND: Gastric adenocarcinoma is a rare diagnosis in childhood. A 14-year-old male patient presented with metastatic gastric adenocarcinoma, and a strong family history of colon cancer. Clinical sequencing of CDH1 and APC were negative. Whole exome sequencing was therefore applied to capture the majority of protein-coding regions for the identification of single-nucleotide variants, small...

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Source

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Identifiers

PMID: 23015295
DOI: 10.1002/pbc.24316
PMCID: PMC4170733

Genes

APC
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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