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Article

Decreased NK Cells in Patients with Head and Neck Cancer Determined in Archival DNA

30 Sept 2012

Abstract excerpt

PURPOSE: Natural killer (NK) cells are a key element of the innate immune system implicated in human cancer. To examine NK cell levels in archived bloods from a study of human head and neck squamous cell carcinoma (HNSCC), a new DNA-based quantification method was developed. EXPERIMENTAL DESIGN: NK cell-specific DNA methylation was identified by analyzing DNA methylation and mRNA array data from purified blood...

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PMID: 23014525
DOI: 10.1158/1078-0432.ccr-12-1008

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