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Article

Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2009

Moxley Joel F, Jewett Michael C, Antoniewicz Maciek R, Villas-Boas Silas G, Alper Hal, Wheeler Robert T, Tong Lily, Hinnebusch Alan G, Ideker Trey, Nielsen Jens, Stephanopoulos Gregory

Abstract excerpt

Genome sequencing dramatically increased our ability to understand cellular response to perturbation. Integrating system-wide measurements such as gene expression with networks of protein-protein interactions and transcription factor binding revealed critical insights into cellular behavior. However, the potential of systems biology approaches is limited by difficulties in integrating metabolic measurements...

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Identifiers

PMID: 19346491
DOI: 10.1073/pnas.0811091106
PMCID: PMC2672541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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