IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells.

Abstract excerpt

In this study we examined the ability of interferon-gamma (IFN-gamma) to regulate mammary epithelial cell growth and gene expression, with particular emphasis on two genes: Maspin (a member of serine protease inhibitor superfamily), and the lysosomal aspartyl endopeptidase cathepsin D (CatD). The protein products of these genes are critically involved in regulation of multitude of biological functions in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis Regulatory Proteins
• Share to Autophagy