Article
Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice.
Toxicologic pathology - 1 Jan 2006
Solano-Lopez Claudia, Zeidler-Erdely Patti C, Hubbs Ann F, Reynolds Steven H, Roberts Jenny R, Taylor Michael D, Young Shih-Houng, Castranova Vincent, Antonini James M
Abstract excerpt
It has been suggested that welding fume (WF) exposure increases lung cancer risk in welders. Epidemiology studies have failed to conclude that WF alone causes lung cancer and animal studies are lacking. We examined the course of inflammation, damage, and repair in the lungs of A/J mice, a lung tumor susceptible strain, caused by stainless steel WF. Mice were exposed by pharyngeal aspiration to 40 mg/kg of WF,...
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