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Article

Contrasting factors on the kinetic path to protein complex formation diminish the effects of crowding agents.

Biophysical journal - 5 Sept 2012

Phillip Yael, Harel Michal, Khait Ruth, Qin Sanbo, Zhou Huan-Xiang, Schreiber Gideon

Abstract excerpt

The crowded environment of cells poses a challenge for rapid protein-protein association. Yet, it has been established that the rates of association are similar in crowded and in dilute solutions. Here we probe the pathway leading to fast association between TEM1 β-lactamase and its inhibitor protein BLIP in crowded solutions. We show that the affinity of the encounter complex, the rate of final complex...

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Identifiers

PMID: 23009850
DOI: 10.1016/j.bpj.2012.08.009
PMCID: PMC3433600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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