Article
Osteopontin polymorphisms and disease course in multiple sclerosis.
Genes and immunity - 1 Jun 2003
Caillier S, Barcellos L F, Baranzini S E, Swerdlin A, Lincoln R R, Steinman L, Martin E, Haines J L, Pericak-Vance M, Hauser S L, Oksenberg J R
Abstract excerpt
Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points...
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