Article
Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
BMC cancer - 24 Sept 2012
Niu Nifang, Schaid Daniel J, Abo Ryan P, Kalari Krishna, Fridley Brooke L, Feng Qiping, Jenkins Gregory, Batzler Anthony, Brisbin Abra G, Cunningham Julie M, Li Liang, Sun Zhifu, Yang Ping, Wang Liewei
Abstract excerpt
BACKGROUND: Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association study (GWAS) for two taxanes, paclitaxel and docetaxel, using 276 lymphoblastoid cell lines (LCLs), followed by genotyping of top candidate SNPs in 874 lung cancer patient samples treated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.