Article
Meta-analyses of the association between cytochrome CYP2C19 loss- and gain-of-function polymorphisms and cardiovascular outcomes in patients with coronary artery disease treated with clopidogrel.
Heart (British Cardiac Society) - 1 Jan 2012
Zabalza Michel, Subirana Isaac, Sala Joan, Lluis-Ganella Carla, Lucas Gavin, Tomás Marta, Masiá Rafel, Marrugat Jaume, Brugada Ramon, Elosua Roberto
Abstract excerpt
AIMS: To perform a meta-analysis of the association between CYP2C19 loss- and gain-of-function variants and cardiovascular outcomes and bleeding in patients with coronary artery disease treated with clopidogrel, and to explore the causes of heterogeneity between studies. METHODS: A comprehensive literature search was conducted. A random-effects model was used to summarise the results. In the presence of...
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