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Article

Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis.

BMJ (Clinical research ed.) - 4 Aug 2011

Bauer Tim, Bouman Heleen J, van Werkum Jochem W, Ford Neville F, ten Berg Jurriën M, Taubert Dirk

Abstract excerpt

OBJECTIVE: To evaluate the accumulated information from genetic association studies investigating the impact of variants of the cytochrome P450 (CYP) 2C19 genotype on the clinical efficacy of clopidogrel. DESIGN: Systematic review and meta-analysis with a structured search algorithm and prespecified eligibility criteria for retrieval of relevant studies; dominant genetic model assumptions and quantitative methods...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21816733
DOI: 10.1136/bmj.d4588
PMCID: PMC3191560

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