Article
Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.
Medical molecular morphology - 1 Jun 2012
Yokoyama Atsushi, Nomura Ryuji, Kurosumi Masafumi, Shimomura Atsushi, Onouchi Takanori, Iizuka-Kogo Akiko, Smits Ron, Fodde Riccardo, Itoh Mditsuyasu, Senda Takao
Abstract excerpt
Adenomatous polyposis coli (Apc) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of Apc, we examined Apc(1638T/1638T) mice that express a truncated Apc lacking the C-terminal domain. The Apc(1638T/1638T) mice were tumor free and exhibited growth retardation. We recently reported abnormalities in thyroid morphology and functions of Apc(1638T/1638T)...
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