Article
Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.
Nucleic acids research - 1 Jun 2011
Pérez-Lluch Sílvia, Blanco Enrique, Carbonell Albert, Raha Debasish, Snyder Michael, Serras Florenci, Corominas Montserrat
Abstract excerpt
An important mechanism for gene regulation involves chromatin changes via histone modification. One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which requires histone methyltranferase complexes (HMT) containing the trithorax-group (trxG) protein ASH2. Mutations in ash2 caus...
Topics
- Animals
- Chromatin
- Drosophila
- Drosophila Proteins
- Genome, Insect
- Histones
- Lysine
- Methylation
- Mutation
- Nuclear Proteins
- Phosphorylation
- Promoter Regions, Genetic
- RNA Polymerase II
- Transcription Factors
- Transcriptional Activation