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Article

Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.

PloS one - 1 Jan 2012

Dumon Stephanie, Walton David S, Volpe Giacomo, Wilson Nicola, Dassé Emilie, Del Pozzo Walter, Landry Josette-Renee, Turner Bryan, O'Neill Laura P, Göttgens Berthold, Frampton Jon

Abstract excerpt

Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of multipotential progenitors. Key to platelet aggregation, CD41 expression also characterises their precursor, the megakaryocyte, and is specifically up regulated during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Thrombopoietin

Source

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Identifiers

PMID: 22952660
DOI: 10.1371/journal.pone.0043300
PMCID: PMC3429474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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