Article
Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia.
Atherosclerosis - 1 Jul 1990
De Knijff P, Stalenhoef A F, Mol M J, Gevers Leuven J A, Smit J, Erkelens D W, Schouten J, Frants R R, Havekes L M
Abstract excerpt
In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantl...
Topics
- Adult
- Aged
- Anticholesteremic Agents
- Apolipoproteins E
- Female
- Heterozygote
- Humans
- Hyperlipoproteinemia Type II
- Lovastatin
- Male
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Sex Factors
- Simvastatin