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Article

Probing the interaction of SR141716A with the CB1 receptor.

The Journal of biological chemistry - 9 Nov 2012

Shim Joong-Youn, Bertalovitz Alexander C, Kendall Debra A

Abstract excerpt

SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent inverse agonist/antagonist activity. Although SR141716A, also known as rimonabant, has been withdrawn from the market due to severe side effects, there remains interest in some of its many potential medical applications. Consequently, it is imperative to understand the mechanism by which SR141716A exerts its inverse agonist...

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Identifiers

PMID: 22995906
DOI: 10.1074/jbc.M112.390955
PMCID: PMC3493917

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