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Article

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition.

Biochemical pharmacology - 15 Jun 2002

McAllister Sean D, Tao Qing, Barnett-Norris Judy, Buehner Kurt, Hurst Dow P, Guarnieri Frank, Reggio Patricia H, Nowell Harmon Katharine W, Cabral Guy A, Abood Mary E

Abstract excerpt

Previous mutation and modeling studies have identified an aromatic cluster in the transmembrane helix (TMH) 3-4-5 region as important for ligand binding at the CB(1) and CB(2) cannabinoid receptors. Through novel mixed mode Monte Carlo/Stochastic Dynamics (MC/SD) calculations, we tested the importance of aromaticity at position 5.39(275) in CB(1). MC/SD calculations were performed on wild-type (WT) CB(1) and two...

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Identifiers

PMID: 12110371
DOI: 10.1016/s0006-2952(02)01031-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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