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Article

Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block.

PloS one - 1 Jan 2012

Yanovsky Yevgenij, Schubring Stephan R, Yao Quiaoling, Zhao Yan, Li Sha, May Andrea, Haas Helmut L, Lin Jian-Sheng, Sergeeva Olga A

Abstract excerpt

Since ancient times ursodeoxycholic acid (UDCA), a constituent of bile, is used against gallstone formation and cholestasis. A neuroprotective action of UDCA was demonstrated recently in models of Alzheimer's disease and retinal degeneration. The mechanisms of UDCA action in the nervous system are poorly understood. We show now that UDCA promotes wakefulness during the active period of the day, lacking this...

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Identifiers

PMID: 22880010
DOI: 10.1371/journal.pone.0042512
PMCID: PMC3412845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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