Article
Can peripheral blood γδ T cells predict osteonecrosis of the jaw? An immunological perspective on the adverse drug effects of aminobisphosphonate therapy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2013
Kalyan Shirin, Quabius Elgar Susanne, Wiltfang Jörg, Mönig Heiner, Kabelitz Dieter
Abstract excerpt
Nitrogen-bisphosphonates (n-BP), often referred to as aminobisphosphonates, are the most commonly prescribed drugs for the treatment of disorders of bone fragility. However, long-term continuous treatment predisposes certain individuals to serious rare side effects, such as bisphosphonate-associated osteonecrosis of the jaw (BAONJ). n-BP use is known to unintentionally activate a subset of innate T cells called...
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