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Article

Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta.

The Journal of biological chemistry - 9 Oct 2009

Guo Peng, Dong Xue-Yuan, Zhao Kewen, Sun Xiaodong, Li Qunna, Dong Jin-Tang

Abstract excerpt

The proto-oncogene MYC plays a critical role in cell proliferation and tumorigenesis, and its down-regulation by transforming growth factor beta (TGFbeta) signaling is necessary for TGFbeta to inhibit cell proliferation. KLF5, on the other hand, is a pro-proliferative basic transcription factor that reverses function to become an anti-proliferative TGFbeta cofactor upon TGFbeta stimulation in epithelial...

Read the complete abstract on PubMed

Topics

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Share to Cell Proliferation
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-myc

Share to RNA, Small Interfering

Share to Transcription, Genetic

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 19684017
DOI: 10.1074/jbc.M109.036160
PMCID: PMC2788876

Genes

KLF5
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta.PMID 19684017Read ↗

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KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2.Semantic proximity Read ↗

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