Article
Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis.
Nature - 1 Jan 2000
Courtney M, Jallat S, Tessier L H, Benavente A, Crystal R G, Lecocq J P
Abstract excerpt
The primary function of alpha 1-antitrypsin (alpha 1-AT), an antiprotease produced by the liver, is the inhibition of neutrophil elastase, a protease capable of hydrolysing most connective tissue components. The importance of alpha 1-AT is demonstrated by the high incidence of early-onset emphysema in individuals with hereditary alpha 1-AT deficiency (Type PiZZ), in whom serum levels of alpha 1-AT are 10-20% of...
Topics
- Amino Acid Sequence
- Emphysema
- Escherichia coli
- Genetic Engineering
- Humans
- Mutation
- Pancreatic Elastase
- Structure-Activity Relationship
- Thrombin
- Thrombosis
- alpha 1-Antitrypsin