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Article

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2012

Hochrath Katrin, Krawczyk Marcin, Goebel Reinhild, Langhirt Miriam, Rathkolb Birgit, Micklich Kateryna, Rozman Jan, Horsch Marion, Beckers Johannes, Klingenspor Martin, Fuchs Helmut, Gailus-Durner Valérie, Wolf Eckhard, Acalovschi Monica, Volmer Dietrich A, Hrabě de Angelis Martin, Lammert Frank

Abstract excerpt

The hepatic phosphatidylcholine (PC) transporter ATP-binding cassette (ABC) B4 flops PC from hepatocytes into bile, and its dysfunction causes chronic cholestasis and fibrosis. Because a nuclear receptor-dependent PC pathway has been determined to exert antidiabetic effects, we now analyzed the r...

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Source

Identifiers

PMID: 22982378
DOI: 10.1096/fj.12-209379

Genes

ABCB4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22982378-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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