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Article

Phosphorylation of ABCB4 impacts its function: insights from disease-causing mutations.

Hepatology (Baltimore, Md.) - 1 Aug 2014

Gautherot Julien, Delautier Danièle, Maubert Marie-Anne, Aït-Slimane Tounsia, Bolbach Gérard, Delaunay Jean-Louis, Durand-Schneider Anne-Marie, Firrincieli Delphine, Barbu Véronique, Chignard Nicolas, Housset Chantal, Maurice Michèle, Falguières Thomas

Abstract excerpt

UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Whereas ABCB4 shares high sequence identity with the multidrug transporter, ABCB1, its N-terminal domain is poorly conserved, leading us to hypothesize a functional specificity of this domain. A database of ABCB4 genotyping in a large series of...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholestasis, Intrahepatic

Share to Hep G2 Cells

Share to Liver Neoplasms

Share to Madin Darby Canine Kidney Cells

Share to Phosphatidylcholines

Share to Pregnancy Complications

Source

Identifiers

PMID: 24723470
DOI: 10.1002/hep.27170

Genes

ABCB4
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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