ABCB4 disease: Many faces of one gene deficiency.

doi:10.1016/j.aohep.2019.09.010

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

ABCB4 disease: Many faces of one gene deficiency.

Annals of hepatology - 1 Jan 2020

Sticova Eva, Jirsa Milan

Abstract excerpt

ATP-binding cassette (ABC) subfamily B member 4 (ABCB4), also known as multidrug resistance protein 3 (MDR3), encoded by ABCB4, is involved in biliary phospholipid secretion, protecting hepatobiliary system from deleterious detergent and lithogenic properties of the bile. ABCB4 mutations altering canalicular ABCB4 protein function and expression may have variable clinical presentation and predispose to several...

Topics

ATP Binding Cassette Transporter, Subfamily B
Age of Onset
Alleles
Bile Duct Diseases
Chemical and Drug Induced Liver Injury
Cholagogues and Choleretics
Cholelithiasis
Cholestasis
Cholestasis, Intrahepatic
Gallbladder Diseases
Humans
Liver Cirrhosis, Biliary
Liver Diseases
Parenteral Nutrition
Pregnancy Complications
Ursodeoxycholic Acid
Female
Male

Source

Open in PubMed

Identifiers

PMID: 31759867
DOI: 10.1016/j.aohep.2019.09.010

Genes

ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics