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Article

Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.

NeuroImage - 1 Mar 2012

Vounou Maria, Janousova Eva, Wolz Robin, Stein Jason L, Thompson Paul M, Rueckert Daniel, Montana Giovanni

Abstract excerpt

Scanning the entire genome in search of variants related to imaging phenotypes holds great promise in elucidating the genetic etiology of neurodegenerative disorders. Here we discuss the application of a penalized multivariate model, sparse reduced-rank regression (sRRR), for the genome-wide detection of markers associated with voxel-wise longitudinal changes in the brain caused by Alzheimer's disease (AD). Using...

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Identifiers

PMID: 22209813
DOI: 10.1016/j.neuroimage.2011.12.029
PMCID: PMC3551466

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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