Article
Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms.
International journal for parasitology. Drugs and drug resistance - 1 Apr 2020
Melville Lynsey A, Redman Elizabeth, Morrison Alison A, Rebecca Chen Pai Chia, Avramenko Russell, Mitchell Sian, Van Dijk Jan, Innocent Giles, Sargison Fiona, Aitken Catriona, Gilleard John S, Bartley Dave J
Abstract excerpt
Benzimidazoles (BZ) have been the anthelmintic of choice for controlling Nematodirus battus infections since their release in the 1950s. Despite heavy reliance on this single anthelmintic drug class, resistance was not identified in this nematode until 2010 (Mitchell et al., 2011). The study aimed to explore the prevalence of BZ-resistance mutations in N. battus from UK sheep flocks using deep amplicon sequencing...
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