Article
Context-specific microRNA analysis: identification of functional microRNAs and their mRNA targets.
Nucleic acids research - 1 Nov 2012
Bossel Ben-Moshe Noa, Avraham Roi, Kedmi Merav, Zeisel Amit, Yitzhaky Assif, Yarden Yosef, Domany Eytan
Abstract excerpt
MicroRNAs (miRs) function primarily as post-transcriptional negative regulators of gene expression through binding to their mRNA targets. Reliable prediction of a miR's targets is a considerable bioinformatic challenge of great importance for inferring the miR's function. Sequence-based prediction algorithms have high false-positive rates, are not in agreement, and are not biological context specific. Here we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.