miR targetome of primary human keratinocytes reveals a function for non-conserved binding sites

Abstract excerpt

<h4>ABSTRACT</h4> The homeostasis of the human body is protected by the skin, where the process of keratinocyte differentiation in outer layers has a crucial role. Cessation of proliferation in the basal layer of keratinocytes and initiation of their subrabasal functions are tightly controlled at the level of gene transcription and message translation. A subset of mRNAs has to be repressed during differentiation,...

Topics

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• Gene Expression Regulation
• Gene Regulatory Networks
• MicroRNAs
• Phenotype
• Transcription Factors
• Transcription, Genetic

Identifiers and source

Literature Corpus work

914c3609-77f7-5336-9cc8-6b897bdf8668

DOI

10.1101/2022.07.04.498673