Article
Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis.
PLoS computational biology - 1 Apr 2010
Lee Younghee, Yang Xinan, Huang Yong, Fan Hanli, Zhang Qingbei, Wu Youngfei, Li Jianrong, Hasina Rifat, Cheng Chao, Lingen Mark W, Gerstein Mark B, Weichselbaum Ralph R, Xing H Rosie, Lussier Yves A
Abstract excerpt
Due to the large number of putative microRNA gene targets predicted by sequence-alignment databases and the relative low accuracy of such predictions which are conducted independently of biological context by design, systematic experimental identification and validation of every functional microRNA target is currently challenging. Consequently, biological studies have yet to identify, on a genome scale, key...
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