Article
Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population.
Carcinogenesis - 1 May 2003
Zhang Jianhui, Schulz Wolfgang A, Li Yan, Wang Rui, Zotz Rainer, Wen Denggui, Siegel David, Ross David, Gabbert Helmut E, Sarbia Mario
Abstract excerpt
NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme, important in the detoxification of environmental carcinogens. A single base substitution (C --> T) polymorphism at nucleotide 609 (null-allele) of NQO1 gene impairs stability and function of the NQO1 protein. To investigate the association of this NQO1 polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC), the NQO1 C609T...
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