Article
No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2010
Akkiz Hikmet, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin, Ülger Yakup, Kaya Berrin Yalinbaş, Sandikçi Macit, Özdil Burhan
Abstract excerpt
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of numerous quinoid compounds into their less toxic form, thus NQO1 protecting cells against oxidative stress. The gene coding for NQO1 has a single nucleotide polymorphism (C-->T) at nucleotide position 609 (proline to serine substitution at position 187 in amino acid sequence (P187S)) (rs1800566) of the NQO1...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Carcinoma, Hepatocellular
- Case-Control Studies
- Female
- Genetic Predisposition to Disease