Article
Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer.
Virchows Archiv : an international journal of pathology - 1 Oct 2012
Klauke Marie-Luise, Hoogerbrugge Nicoline, Budczies Jan, Bult Peter, Prinzler Judith, Radke Cornelia, van Krieken J Han J M, Dietel Manfred, Denkert Carsten, Müller Berit Maria
Abstract excerpt
Poly(ADP-ribose) polymerase 1 (PARP) is a key element of the single-base excision pathway for repair of DNA single-strand breaks. To compare the cytoplasmic and nuclear poly(ADP-ribose) expression between familial (BRCA1, BRCA2, or non BRCA1/2) and sporadic breast cancer, we investigated 39 sporadic and 39 familial breast cancer cases. The two groups were matched for hormone receptor status and human epidermal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.