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Article

Cytoplasmic PARP‐1 promotes pancreatic cancer tumorigenesis and resistance

8 Jan 2019

Abstract excerpt

The poly(ADP-ribose) polymerases (PARP) play important roles in repairing damaged DNA during intrinsic cell death. We recently linked PARP-1 to death receptor (DR)-activated extrinsic apoptosis, the present studies sought to elucidate the function of cytoplasmic PARP-1 in pancreatic cancer tumorigenesis and therapy. Using human normal and pancreatic cancer tissues, we analyzed the prevalence of cytoplasmic PARP-1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30614530
DOI: 10.1002/ijc.32108

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