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Article

Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits.

Physiological genomics - 1 Nov 2012

Warden Craig H, Gularte-Mérida Rodrigo, Fisler Janis S, Hansen Susan, Shibata Noreene, Le Anh, Medrano Juan F, Stern Judith S

Abstract excerpt

Linkage mapping in a backcross of {Brown Norway [BN/Crl (BN)] × ZUC-Lepr (faSte) (ZUC)} × ZUC identified a male-specific quantitative trait locus (QTL) for urinary albumin excretion (UAE) on rat chromosome 1. A homozygous ZUC.BN-(D1Rat42-D1Rat90)/Ste congenic was produced containing BN donor alleles from 135 to 276 Mb from chromosome 1 on the ZUC background. We observed threefold higher urinary...

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Share to Animals, Congenic
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crosses, Genetic

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Share to Rats, Zucker

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Source

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Identifiers

PMID: 22968639
DOI: 10.1152/physiolgenomics.00134.2011
PMCID: PMC3615576

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ACR

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