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Article

Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008

Chen Lina, Lawlor Debbie A, Lewis Sarah J, Yuan Wei, Abdollahi Mohammad R, Timpson Nicholas J, Day Ian N M, Ebrahim Shah, Smith George Davey, Shugart Yin Y

Abstract excerpt

Depression is common and a major cause of morbidity and mortality and is also known to have serious effects on quality of life. Both clinical and pharmacologic studies have implicated the role of brain-derived neurotrophic factor (BDNF) as a susceptibility locus for the development of mental illness, including depression, bipolar disorder, and schizophrenia. Population-based genetic studies have examined the...

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Identifiers

PMID: 18205169
DOI: 10.1002/ajmg.b.30686

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.PMID 18205169Read ↗

No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.Semantic proximity Read ↗

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level.Semantic proximity Read ↗

BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.Semantic proximity Read ↗

The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels.Semantic proximity Read ↗

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.Semantic proximity Read ↗

Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression.Semantic proximity Read ↗

Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.Semantic proximity Read ↗

Brain derived neurotrophic factor (BDNF) Val66Met polymorphism is not risk factor for bipolar disorderSemantic proximity Read ↗

Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response.Semantic proximity Read ↗

The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.Semantic proximity Read ↗

No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression.Semantic proximity Read ↗

The G-712A polymorphism of brain-derived neurotrophic factor is associated with major depression but not schizophrenia.Semantic proximity Read ↗

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