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Article

Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease.

American journal of nephrology - 1 Jan 2012

Bostrom Meredith A, Perlegas Peter, Lu Lingyi, Hicks Pamela J, Hawkins Greg, Ng Maggie C Y, Langefeld Carl D, Freedman Barry I, Bowden Donald W

Abstract excerpt

BACKGROUND: African-Americans (AAs) are predisposed to non-diabetic (non-DM) end-stage renal disease (ESRD), and studies have shown a genetic component to this risk. Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis. METHODS: We assessed the contribution of coding variants in ACTN4 to non-DM ESRD risk in AAs. Nineteen exons,...

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Source

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Identifiers

PMID: 22965004
DOI: 10.1159/000342205
PMCID: PMC3510331

Genes

ACTN4
APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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