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Article

Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans.

Human genetics - 1 Nov 2016

Guan Meijian, Ma Jun, Keaton Jacob M, Dimitrov Latchezar, Mudgal Poorva, Stromberg Mary, Bonomo Jason A, Hicks Pamela J, Freedman Barry I, Bowden Donald W, Ng Maggie C Y

Abstract excerpt

African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD) compared to European Americans. Genome-wide association studies have identified variants associated with diabetic and non-diabetic kidney diseases. Nephropathy loci, including SLC7A9, UMOD, and SHROOM3, have been implicated in the maintenance of normal glomerular and renal tubular structure and function. Herein, 47 genes...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetic Nephropathies

Share to Glomerular Basement Membrane

Share to Kidney Failure, Chronic

Share to Kidney Tubules, Distal

Share to Matrix Metalloproteinase 2

Share to Podocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 27461219
DOI: 10.1007/s00439-016-1714-2
PMCID: PMC5053912

Genes

ARHGAP24
CLDN8
ACAD11
APOL1
MMP2
NPHP3
SHROOM3
UMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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