Article
The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.
Genes & development - 15 May 2011
Hodge Christine A, Tran Elizabeth J, Noble Kristen N, Alcazar-Roman Abel R, Ben-Yishay Rakefet, Scarcelli John J, Folkmann Andrew W, Shav-Tal Yaron, Wente Susan R, Cole Charles N
Abstract excerpt
Nuclear export of messenger RNA (mRNA) occurs by translocation of mRNA/protein complexes (mRNPs) through nuclear pore complexes (NPCs). The DEAD-box protein Dbp5 mediates export by triggering removal of mRNP proteins in a spatially controlled manner. This requires Dbp5 interaction with Nup159 in NPC cytoplasmic filaments and activation of Dbp5's ATPase activity by Gle1 bound to inositol hexakisphosphate (IP(6))....
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