Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia.

doi:10.1007/978-1-4939-6703-2_20

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Article

Recurrent Cytogenetic Abnormalities in Myeloproliferative Neoplasms and Chronic Myeloid Leukemia.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Swansbury John

Abstract excerpt

The commonest types of myeloproliferative neoplasm (MPN) have remarkably similar recurrent chromosome abnormalities, but with varying incidence and prognostic implications. After a clear decade of treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors, the differing prognostic implications of abnormalities additional to the Ph chromosome are being revealed. This chapter provides a description...

Topics

Chromosome Aberrations
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Molecular Targeted Therapy
Myeloproliferative Disorders
Translocation, Genetic

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PMID: 27910028
DOI: 10.1007/978-1-4939-6703-2_20

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