Article
Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
Stroke - 1 Jun 2010
Hashikata Hirokuni, Liu Wanyang, Inoue Kayoko, Mineharu Yohei, Yamada Shigeki, Nanayakkara Shanika, Matsuura Norio, Hitomi Toshiaki, Takagi Yasushi, Hashimoto Nobuo, Miyamoto Susumu, Koizumi Akio
Abstract excerpt
BACKGROUND AND PURPOSE: Genetic factors are important determinants of intracranial aneurysm (IA). Recently, a multinational, genome-wide association study identified 3 loci associated with IA, located on 2q (rs700651), 8q (rs10958409), and 9p (rs1333040 and rs10757278). The aim of this study was to evaluate these associations. METHODS: Familial and sporadic cases were investigated. Familial cases, consisting of...
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